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Updated: Aug 29, 2025

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
Published on: January 19, 2024
Practical application of mathematical calculations and statistical methods for the routine haematology laboratory
Ruth Padmore1,2,3, Katryna Petersen1, Chris Campbell1
1Eastern Ontario Regional Laboratory Association, Ottawa, Ontario, Canada.
Background:
Statistical analyses are embedded as critical functions in the routine haematology laboratory.
Aim:
This educational article is aimed at providing an overview of these topics and practical application examples.
Materials, Methods, And Results:
Topics covered include mathematical conversion between units, maintaining a quality control (QC) system, statistical methods for reagent validation, and determining uncertainty of measurement (UoM).
Discussion:
Additional considerations may be required when a regional laboratory program is in place, such as the harmonization of INR results and determination of therapeutic reference intervals for unfractionated heparin therapy.
Conclusion:
The coauthors of this manuscript are fortunate to be part of regional network of hospital laboratories, the Eastern Ontario Regional Laboratory Association (EORLA).
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