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Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

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Published on: January 26, 2016

Cyclic Peptide Screening Methods for Preclinical Drug Discovery.

Xinting Li¹, Timothy W Craven¹, Paul M Levine¹

¹Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington 98195, United States.

Journal of Medicinal Chemistry

|September 8, 2022

Summary

Cyclic peptides offer stable scaffolds for drug discovery, targeting challenging proteins. Advanced screening methods are accelerating the development of these promising therapeutic agents.

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Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

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Last Updated: Aug 29, 2025

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Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

Area of Science:

Medicinal Chemistry
Drug Discovery
Biotechnology

Background:

Cyclic peptides are versatile scaffolds in drug discovery due to their stability and synthetic accessibility.
They are effective in modulating challenging targets like protein-protein interactions and previously undruggable targets.
The field is rapidly advancing with new screening technologies.

Purpose of the Study:

To review cyclic peptides approved for clinical use.
To highlight synthetic strategies for creating novel cyclic peptide libraries.
To discuss emerging screening methods and future prospects for cyclic peptide therapeutics.

Main Methods:

Review of clinical cyclic peptides from the past two decades.
Discussion of synthetic chemistry approaches for de novo cyclic peptide library generation.
Exploration of advanced screening technologies such as phage display, mRNA display, and in silico methods.

Main Results:

Several cyclic peptides have gained clinical approval, demonstrating therapeutic potential.
Diverse synthetic chemistries enable the creation of vast cyclic peptide libraries.
Novel screening platforms significantly enhance the identification of potent cyclic peptide drug candidates.

Conclusions:

Cyclic peptides represent a significant frontier in modern medicine and drug development.
Continued innovation in synthesis and screening will drive the market viability of cyclic peptide therapeutics.
Addressing current advantages and disadvantages is crucial for successful clinical translation.