[Amyloid goitre, a benign entity with fast growth].

Area of Science:

• Endocrinology
• Pathology

Background:

• Amyloid goitre is a rare benign thyroid condition.
• It involves rapid thyroid enlargement from amyloid deposition.
• Symptoms include dyspnea, dysphagia, and dysphonia.

Purpose of the Study:

• To present three cases of amyloid goitre.
• To estimate the incidence of amyloid goitre.
• To describe the morphology and associated conditions.

Main Methods:

• Case series analysis.
• Histopathological examination of thyroid tissue.
• Review of patient medical history.

Main Results:

• Three cases of amyloid goitre were diagnosed.
• Morphology showed thyroid follicles, adipose tissue, and amyloid.
• AA amyloid accumulation was confirmed, linked to Crohn's disease, juvenile rheumatoid arthritis, and chronic renal disease.
• One case had papillary microcarcinoma.

Conclusions:

• Amyloid goitre is infrequent but important in goitre differential diagnosis.
• Consider amyloid goitre in patients with chronic underlying diseases.
• Early diagnosis is crucial for managing associated symptoms and conditions.