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Updated: Aug 29, 2025

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Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments
Published on: November 12, 2019
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Spike timing-based regulation of thalamocortical signaling
Isis S Wyche1, Daniel H O'Connor1
1The Solomon H. Snyder Department of Neuroscience, Zanvyl Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Neuron
|September 9, 2022
Abstract:
For decades, thalamic burst and tonic spiking modes have been theorized to regulate sensory signaling in the thalamocortical circuit. In this issue of Neuron, Borden et al. demonstrate a timing-based mechanism by which thalamic spiking mode controls sensory responses in the awake cortex.

