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Updated: Aug 29, 2025

Sample Preparation using a Lipid Monolayer Method for Electron Crystallographic Studies
Published on: November 20, 2021
Insight into the Mammalian Aquaporin Interactome
Susanna Törnroth-Horsefield1, Clara Chivasso2, Helin Strandberg1
1Division of Biochemistry and Structural Biology, Lund University, 22 100 Lund, Sweden.
Abstract:
Aquaporins (AQPs) are a family of transmembrane water channels expressed in all living organisms. AQPs facilitate osmotically driven water flux across biological membranes and, in some cases, the movement of small molecules (such as glycerol, urea, CO2, NH3, H2O2). Protein-protein interactions play essential roles in protein regulation and function. This review provides a comprehensive overview of the current knowledge of the AQP interactomes and addresses the molecular basis and functional significance of these protein-protein interactions in health and diseases. Targeting AQP interactomes may offer new therapeutic avenues as targeting individual AQPs remains challenging despite intense efforts.
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