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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
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Related Experiment Video

Updated: Aug 29, 2025

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements
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Mechano-Sensing Channel PIEZO2 Enhances Invasive Phenotype in Triple-Negative Breast Cancer.

Eriko Katsuta1, Kazuaki Takabe1,2,3,4,5,6, Marija Vujcic7

  • 1Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.

International Journal of Molecular Sciences
|September 9, 2022
PubMed
Summary
This summary is machine-generated.

High PIEZO2 channel expression in triple-negative breast cancer (TNBC) promotes cell motility and metastasis. This suggests PIEZO2 is a potential therapeutic target for improving TNBC patient outcomes.

Keywords:
PIEZOmechano-signalingmetastasistriple-negative breast cancer

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Area of Science:

  • Cellular Mechanotransduction
  • Oncology
  • Molecular Biology

Background:

  • PIEZO channels are mechanically gated ion channels involved in cellular responses.
  • PIEZO2's specific role in breast cancer progression remained largely unexplored.

Purpose of the Study:

  • To investigate the role of PIEZO2 in breast cancer, particularly in triple-negative breast cancer (TNBC).
  • To determine the clinical relevance and functional impact of PIEZO2 expression in TNBC.

Main Methods:

  • Analysis of a public breast cancer patient dataset for PIEZO2 expression correlation with survival.
  • In vitro and in vivo experiments using PIEZO2-overexpressed breast cancer cells.

Main Results:

  • High PIEZO2 expression correlated with poor survival in TNBC patients.
  • PIEZO2 overexpression enhanced cell motility, invasion, and metastasis in TNBC models.
  • PIEZO2 promoted epithelial-mesenchymal transition (EMT) by upregulating SNAIL and Vimentin, and downregulating E-cadherin.
  • PIEZO2 activation of Akt signaling was observed in TNBC cells.

Conclusions:

  • PIEZO2 activation enhances SNAIL stabilization via Akt, promoting EMT and increasing metastatic potential in TNBC.
  • PIEZO2 is linked to poor clinical outcomes in TNBC patients, highlighting its potential as a therapeutic target.