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Updated: Aug 29, 2025

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines
Published on: November 25, 2017
N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry
Federico Cuccu1, Francesco Basoccu1, Claudia Fattuoni1
1Department of Chemical and Geological Sciences, University of Cagliari, 09124 Monserrato, Italy.
Abstract:
The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to present a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely N-formylsaccharin, N-acetylsaccharin, and N-propionylsaccharin. This protocol furnishes a valuable solvent-free alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup.
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