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Updated: Aug 29, 2025

Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass
Yuan Liang1, Ruili Yu1,2, Rui He1,3
1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, China.
Objective:
Roux-en-Y gastric bypass is an effective intervention for metabolic disorder. We aim to elucidate whether ghrelin contributes to weight reduction, and glycemic and lipid control after Roux-en-Y gastric bypass (RYGB).
Design:
Four-week-old WT and Ghrl-TSC1-/- mice were fed high fat diet for 12 weeks before surgery, and continued to be on the same diet for 3 weeks after surgery. Body weight, food intake, glycemic and lipid metabolism were analyzed before and after surgery.
Results:
Gastric and circulating ghrelin was significantly increased in mice with RYGB surgery. Hypoghrelinemia elicited by deletion of TSC1 to activate mTOR signaling in gastric X/A like cells demonstrated no effect on weight reduction, glycemic and lipid control induced by Roux-en-Y gastric bypass surgery.
Conclusion:
Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass.
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