[Research progress in B10 cells and autoimmune diseases]

Regulatory B cells (Bregs) are a group of B cells with negative immune regulation, which produce negative regulatory cytokines, such as interleukin-10 (IL-10), transform growth factor β (TGF- β), or participate in immune regulation and inhibit inflammatory response by intercellular activities. B10 cells are a kind of Bregs that generates IL-10. In recent years, a large number of studies have reported that B10 cells are involved in the development of a variety of autoimmune diseases. Here, we make a systematic review of the origin and immune mechanism of B10 cells, their roles in autoimmune diseases (rheumatoid arthritis, inflammatory bowel disease and Sjogren's syndrome, etc.) and regulations, coupled with its applications in the treatment of autoimmune diseases.We also discussed the B10 cells as a potential method feasible for treating autoimmune diseases.