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Robert R A Bolt1, Sarah E Raby-Buck1, Katharine Ingram2
1Department of Pharmaceutical and Biological Chemistry, University College London (UCL), School of Pharmacy, 29-39 Brunswick Square, Bloomsbury, London, WC1N 1AX, UK.
Angewandte Chemie (International Ed. in English)
|September 9, 2022
Abstract:
The nickel catalyzed Suzuki-Miyaura-type coupling of aryl sulfamates and boronic acid derivatives enabled by temperature-controlled mechanochemistry via the development of a programmable PID-controlled jar heater is reported. This base-metal-catalyzed, solvent-free, all-under-air protocol was also scaled 200-fold using twin-screw extrusion technology affording decagram quantities of material.