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Chlorpropamide alcohol flushing: a normal response?

P J Hoskins, P G Wiles, H P Volkmann

    Clinical Science (London, England : 1979)
    |July 1, 1987
    PubMed
    Summary
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    Chlorpropamide alcohol flushing, a reaction to ethanol, appears to be a normal phenomenon in young, healthy non-diabetic adults. This study investigated the flushing response to determine its prevalence in this demographic.

    Area of Science:

    • Pharmacology
    • Endocrinology
    • Human Physiology

    Background:

    • The association between chlorpropamide alcohol flushing and non-insulin dependent diabetes is not fully understood.
    • Alcohol-induced facial flushing and temperature changes are influenced by chlorpropamide plasma levels and baseline facial temperature.

    Purpose of the Study:

    • To investigate the prevalence of chlorpropamide alcohol flushing in young, healthy non-diabetic adults.
    • To determine if chlorpropamide alcohol flushing is a normal physiological response in this population.

    Main Methods:

    • A double-blind, placebo-controlled, cross-over study was conducted on 23 non-diabetic subjects.
    • Subjects received either chlorpropamide (250 mg twice daily for 2 days) or a placebo, followed by 8 g of ethanol.
    • A pilot study in nine subjects ensured the safety and efficacy of the chlorpropamide dosage.

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    Main Results:

    • All 32 subjects (including pilot study participants) exhibited chlorpropamide alcohol flushing.
    • The flushing response met predefined criteria, including a significant facial temperature rise and subjective/observer assessments.
    • 26 out of 32 subjects fulfilled all three criteria for chlorpropamide alcohol flushing.

    Conclusions:

    • Chlorpropamide alcohol flushing appears to be a common and normal physiological response in young, healthy non-diabetic adults.
    • The study suggests that this flushing phenomenon is not exclusive to diabetic individuals.