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Effects of Hepatitis B Virus Infection on Patients with COVID-19: A Meta-Analysis

Yang Yu1, Xingzhao Li2, Taihu Wan3

  • 1Department of Hepatobiliary and Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin Province, China.

Digestive Diseases and Sciences
|September 9, 2022
PubMed

Insights

Hepatitis B virus (HBV) infection significantly increases mortality and severity in COVID-19 patients. Liver function indices require close monitoring during treatment for these patients.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • The COVID-19 pandemic presents unique challenges for patients with pre-existing Hepatitis B virus (HBV) infection.
  • Understanding the impact of HBV on COVID-19 outcomes is crucial for patient management.

Approach:

  • A comprehensive meta-analysis was conducted using data from PubMed, Embase, and Web of Science.
  • The study adhered to the PRISMA guideline, employing a random-effects model for analysis.
  • 37,696 patients were analyzed, comparing 2,591 COVID-19 patients with HBV to 35,105 COVID-19 patients without HBV.

Key Points:

  • COVID-19 patients with HBV exhibited significantly higher in-hospital mortality (OR=2.04) and a greater likelihood of developing severe disease (OR=1.90).
  • HBV infection was associated with elevated liver function markers, including ALT, AST, total bilirubin, direct bilirubin, and LDH.
  • Elevated liver enzymes (ALT, AST, bilirubin, LDH) were significantly higher in COVID-19 patients with HBV.

Conclusions:

  • COVID-19 patients co-infected with HBV require heightened clinical attention.
  • Close monitoring of liver function tests is essential for managing COVID-19 patients with HBV.
Abstract

Keywords:
COVID-19Hepatitis B virusLiver functionMeta-analysis

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