A Comparative Study on the Potential of Unsupervised Deep Learning-based Feature Selection in Radiomics

In Radiomics, deep learning-based systems for medical image analysis play an increasing role. However, due to the better explainability, feature-based systems are still preferred, especially by physicians. Often, high-dimensional data and low sample size pose different challenges (e.g. increased risk of overfitting) to machine learning systems. By removing irrelevant and redundant features from the data, feature selection is an effective way of pre-processing. The research in this study is focused on unsupervised deep learning-based methods for feature selection. Five recently proposed algorithms are compared regarding their applicability and efficiency on seven data sets in three different sample applications. It was found that deep learning-based feature selection leads to improved classification results compared to conventional methods, especially for small feature subsets. Clinical Relevance - The exploration of distinctive features and the ability to rank their importance without the need for outcome information is a potential field of application for unsupervised feature selection methods. Especially in multiparametric radiology, the number of features is increasing. The identification of new potential biomarkers is important both for treatment and prevention.