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Anterior segment autonomic dysfunction in ocular hypertension
Documenta Ophthalmologica. Advances in Ophthalmology
|January 1, 1986
Summary
Autonomic nerve dysfunction, specifically parasympathetic deficits, is linked to ocular hypertension in patients with narrow irido-corneal angles. This suggests a role for autonomic dysfunction in primary glaucoma development.
Area of Science:
- Ophthalmology
- Autonomic Neuroscience
Background:
- Ocular hypertension is a risk factor for primary open-angle glaucoma.
- Autonomic dysfunction has been implicated in the pathogenesis of glaucoma.
Purpose of the Study:
- To assess autonomic nerve function in the anterior segment of the eye in patients with ocular hypertension.
- To investigate the relationship between autonomic dysfunction and irido-corneal angle width in ocular hypertension.
Main Methods:
- Pupil cycle time was measured in 189 patients with ocular hypertension and 70 control subjects.
- Patients were categorized based on irido-corneal angle width (narrow vs. wide).
Main Results:
- Significant parasympathetic dysfunction was observed in ocular hypertensive patients with narrow irido-corneal angles.
- No significant parasympathetic dysfunction was found in ocular hypertensive patients with wide irido-corneal angles.
Conclusions:
- Autonomic dysfunction, particularly parasympathetic deficits, may contribute to the pathogenesis of primary glaucomas.
- Irido-corneal angle width is a critical factor in the manifestation of autonomic dysfunction in ocular hypertension.