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Metal-organic frameworks based surface-enhanced Raman spectroscopy technique for ultra-sensitive biomedical trace

Yuna Zhang1, Cuili Xue1, Yuli Xu1

  • 1Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240 China.

Nano Research
|September 12, 2022
PubMed
Summary

Metal-organic frameworks (MOFs) are combined with surface-enhanced Raman scattering (SERS) to create advanced sensors. This review covers MOF synthesis for SERS substrates and their use in ultra-sensitive trace detection.

Keywords:
biomedical trace detectionmetal-organic framework (MOF)surface-enhanced Raman scattering (SERS)synthesis strategy

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Nanotechnology

Background:

  • Metal-organic frameworks (MOFs) offer unique microstructures and properties, driving significant research interest.
  • Surface-enhanced Raman scattering (SERS) is a highly sensitive spectroscopic technique for trace detection.

Purpose of the Study:

  • To summarize MOF synthesis strategies for fabricating SERS-active substrates.
  • To review the applications of MOF-based SERS substrates in ultra-sensitive biomedical trace detection.

Main Methods:

  • Review of literature on MOF synthesis for SERS applications.
  • Analysis of studies utilizing MOF-SERS for biomedical trace detection.

Main Results:

  • MOFs can be effectively synthesized into SERS-active substrates.
  • MOF-SERS substrates demonstrate significant potential for ultra-sensitive biomedical detection.

Conclusions:

  • Combining MOFs with SERS enhances sensing performance and broadens application scope.
  • Discussion of barriers, advantages, disadvantages, and future prospects for MOF-SERS technology.