Squamous cell carcinoma of the prostate with SMARCA4 alteration in a Japanese patient
Related Experiment Video For SMARCA4 mutation
Updated: Aug 29, 2025
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Yuta Kaneko1, Takeo Kosaka1, Kohei Nakamura2
1Department of Urology Keio University School of Medicine Tokyo Japan.
Introduction:
Squamous cell carcinoma of the prostate is very rare. Due to difficulty in diagnosis, it is often detected in advanced stages. Effective treatment of squamous cell carcinoma and the genetic profiling has not yet been established.
Case Presentation:
We experienced the case of a 79-year-old man who was diagnosed with primary squamous cell carcinoma of the prostate. He had multiple lymph node metastases, liver metastases, and lung metastases, and he was treated with gemcitabine and carboplatin. However, he had poor patient status: it became difficult to continue after one course, and best supportive care was provided. We also performed targeted next-generation sequencing of 160 cancer-related genes and detected SMARCA4 mutation.
Conclusion:
This is the first study reporting the genomic profiling of squamous cell carcinoma of prostate in Japan.
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