Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

628
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
628
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

888
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
888
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

65
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
65
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.3K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.3K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

12.1K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
12.1K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

23
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
23

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Un uncommon diagnosis of liver masses.

Internal and emergency medicine·2026
Same author

Exocrine Pancreatic Insufficiency: Postoperative Complication Emerging Decades after Surgery?

Maedica·2025
Same author

Cholelithiasis through the skin: a case of cholecystocutaneous fistula.

Internal and emergency medicine·2025
Same author

Schmidt´s syndrome found by tan: a case report.

The Pan African medical journal·2024
Same author

Assessment of patient-reported outcomes measures in heart failure: a systematic review.

Heart failure reviews·2024
Same author

Why Is Whipple's Disease Still a Challenging Diagnosis? A Case Report and Brief Review of Literature.

Cureus·2023

Related Experiment Video

Updated: Aug 29, 2025

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.4K

Virus and Autoimmunity: Can SARS-CoV-2 Trigger Large Vessel Vasculitis?

João Lázaro Mendes1, Gabriela Venade1, Paula Manuel1

  • 1Internal Medicine Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.

European Journal of Case Reports in Internal Medicine
|September 12, 2022
PubMed
Summary

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can trigger large vessel vasculitis (LVV) in susceptible individuals. Prompt diagnosis and treatment of autoimmune diseases post-COVID-19 improve patient prognosis.

Keywords:
Autoimmune diseasesCOVID-19case reportvasculitis

More Related Videos

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

2.9K
Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
10:50

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

7.8K

Related Experiment Videos

Last Updated: Aug 29, 2025

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.4K
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

2.9K
Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
10:50

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

7.8K

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Immunology

Background:

  • Viral infections, including SARS-CoV-2, are increasingly linked to autoimmune diseases.
  • Rheumatic conditions like vasculitis and arthritis have been observed following COVID-19.
  • Large vessel vasculitis (LVV) is a less commonly reported post-viral autoimmune manifestation.

Purpose of the Study:

  • To report a case of large vessel vasculitis (LVV) temporally associated with SARS-CoV-2 infection.
  • To highlight the potential for SARS-CoV-2 to trigger autoimmune responses beyond typical rheumatic manifestations.
  • To emphasize the importance of considering LVV in patients with post-viral inflammatory syndromes.

Main Methods:

  • Case report of a 19-year-old woman with symptoms 5 weeks after mild COVID-19.
  • Diagnostic work-up included serological tests, computed tomography (CT), and fluorodeoxyglucose positron emission tomography (FDG-PET).
  • Treatment involved prednisolone, with subsequent normalization of symptoms and laboratory values.

Main Results:

  • The patient presented with fatigue, malaise, chest, and low back pain, indicative of a proinflammatory state.
  • Imaging revealed inflammatory changes in the aorta and proximal iliac and renal arteries, consistent with LVV.
  • Prednisolone treatment led to symptom resolution and normalization of inflammatory markers.

Conclusions:

  • Recent SARS-CoV-2 infection can precipitate large vessel vasculitis, such as Takayasu arteritis.
  • Early recognition and differential diagnosis of LVV are crucial to exclude mimics.
  • Physicians must be aware of the broad spectrum of autoimmune diseases potentially triggered by SARS-CoV-2 for timely intervention and improved outcomes.