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Updated: Aug 29, 2025
06:24
Paired Cisterna Magna Nanoinjection and Laser Speckle Contrast Imaging Assay to Study Cerebral Blood Flow Regulation In Vivo
Published on: July 8, 2025
414
Cerebral Blood Flow Alterations and Obesity: A Systematic Review and Meta-Analysis
Yu-Shun Qiao1, Xingyao Tang2, Yin-He Chai1
1Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Journal of Alzheimer'S Disease : JAD
|September 12, 2022
Summary
Obesity is linked to reduced cerebral blood flow (CBF), impacting cognitive function. This meta-analysis confirms a negative association between body mass index (BMI) and CBF, highlighting global and regional reductions in the brain for obese individuals.
Area of Science:
- Neuroscience
- Metabolic Disorders
Background:
- Obesity is increasingly recognized for its role in cognitive impairment and dementia, with cerebral blood flow (CBF) reduction being a key factor.
- Existing research on the relationship between obesity and CBF presents inconsistent findings, necessitating a comprehensive analysis.
Approach:
- A systematic review and meta-analysis were conducted, screening 18 studies with 24,866 participants.
- Both cross-sectional and longitudinal studies were evaluated to assess differences in CBF between obese and normal-weight individuals.
Key Points:
- A negative association was found between body mass index (BMI) and CBF (β = -0.31).
- Obese individuals exhibited global and regional reductions in CBF, particularly in the frontal lobe, temporal and parietal lobes, cerebellum, hippocampus, and thalamus.
- BMI demonstrated a stronger inverse association with CBF compared to waist circumference or waist-to-hip ratio.
Conclusions:
- The study confirms an inverse relationship between BMI and CBF, suggesting that obesity negatively impacts brain circulation.
- These CBF alterations in obese individuals may contribute to cognitive deficits and the development of dementia.
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