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Manipulation of Nitric Oxide Levels via a Modified Hydroxyethyl Starch Molecule
Ugur Aksu1, Can Ince2, Silke Baasner3
1Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey.
The Journal of Surgical Research
|September 12, 2022
Summary
This study introduces S-NO-HES, a novel nitric oxide (NO) donor fluid. S-NO-HES demonstrated effective NO release and vasodilatory effects, showing promise as a potential therapeutic agent.
Area of Science:
- Biochemistry
- Pharmacology
- Cardiovascular Research
Background:
- Nitric oxide (NO) donors show promise in treating shock, but no such medications are currently available.
- Thiol-nitrosothiol-hydroxyethyl starch (S-NO-HES) is a novel molecule designed to release NO.
Purpose of the Study:
- To assess the in vitro NO-releasing capabilities of S-NO-HES under simulated physiological conditions.
- To evaluate S-NO-HES as a potential NO donor fluid.
Main Methods:
- Investigated S-NO-HES NO release at varying temperatures (34°C, 37°C, 41°C) in blood.
- Assessed NO release with ascorbic acid and amylase.
- Evaluated vasodilatory effects in isolated aortic rings and cardiac function in Langendorff-perfused hearts.
Main Results:
- S-NO-HES exhibited consistent NO release across tested temperatures.
- S-NO-HES demonstrated dose-dependent vasodilation in aortic rings.
- S-NO-HES increased heart rate and reduced cardiac action potential duration (QTc-B values).
Conclusions:
- The S-NO-HES molecule effectively releases NO.
- Further studies are needed to determine S-NO-HES efficacy in conditions like septic shock.
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