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Is There a Place for Hyperbaric Oxygen Therapy?
Kinjal N Sethuraman1, Ryan Smolin2, Sharon Henry3
1University of Maryland Medical Center, Hyperbaric and Dive Medicine, 22 South Greene Street, Baltimore, MD 2120, USA.
Advances in Surgery
|September 12, 2022
Summary
Hyperbaric oxygen therapy (HBOT) delivers 100% oxygen in a pressurized chamber, acting as a drug to treat hypoxic tissues. Dosage, including depth and duration, is crucial for HBOT
Area of Science:
- Hyperbaric medicine
- Oxygen therapy
- Physiology
Background:
- Hyperbaric oxygen therapy (HBOT) utilizes 100% oxygen inhalation within a pressurized chamber.
- The chamber functions as a device for precise oxygen 'dosing'.
- HBOT can be a standalone treatment or an adjunct to conventional therapies.
Purpose of the Study:
- To explain the physiological mechanisms of HBOT.
- To highlight the importance of dose-dependent effects in HBOT.
- To outline the therapeutic applications of HBOT.
Main Methods:
- Administration of 100% oxygen under increased atmospheric pressure.
- Controlled treatment duration and depth within a hyperbaric chamber.
- Monitoring physiological responses to hyperbaric hyperoxia.
Main Results:
- Oxygen acts as a therapeutic agent, with effects contingent on dose (depth and duration).
- HBOT facilitates oxygen-rich plasma delivery to hypoxic tissues.
- Potential to prevent reperfusion injury and enhance immune response.
Conclusions:
- HBOT is a versatile therapeutic modality with dose-dependent physiological effects.
- It supports tissue oxygenation, immune function, and wound healing.
- Key applications include preventing reperfusion injury and promoting cellular repair.
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