Definition of delayed-onset neurologic sequelae: A review article

Area of Science:

• Neurology
• Toxicology
• Medical Research

Background:

• Delayed-onset neurologic sequelae (DNS) is a severe complication of carbon monoxide (CO) poisoning.
• Existing research on DNS is abundant but lacks a consistent definition and symptomology.
• The ambiguity surrounding DNS hinders effective diagnosis and treatment.

Purpose of the Study:

• To systematically review and identify the diverse symptoms and definitions of DNS associated with carbon monoxide poisoning in existing literature.
• To consolidate current understanding of how DNS is defined and diagnosed across various studies.
• To provide a foundation for developing standardized diagnostic criteria.

Main Methods:

• A comprehensive literature search was conducted using PubMed and Scopus databases.
• Studies were screened by title and abstract, followed by full-text review to ensure inclusion criteria were met.
• Data extraction was performed by a single author, focusing on original, full-text research studies in English with clear DNS definitions.

Main Results:

• The review encompassed 127 studies investigating delayed-onset neurologic sequelae.
• Identified symptoms of DNS were categorized into twelve distinct groups, with general neurological and cognitive/learning dysfunctions being most prevalent.
• Commonly used diagnostic approaches included imaging studies, clinical assessments, and neuropsychiatric testing.

Conclusions:

• The current body of literature demonstrates significant inconsistency in defining DNS resulting from carbon monoxide toxicity.
• Standardizing the definition and diagnostic criteria for DNS is crucial for advancing clinical research and patient care.
• Establishing clear guidelines will facilitate more accurate diagnosis, targeted treatment, and reliable outcome measurement.