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Automated Segmentation of Cortical Grey Matter from T1-Weighted MRI Images
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Deep learning with multiresolution handcrafted features for brain MRI segmentation.

Imene Mecheter1, Maysam Abbod1, Abbes Amira2

  • 1Department of Electronic and Computer Engineering, Brunel University London, Uxbridge, UK.

Artificial Intelligence in Medicine
|September 13, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces a new method to improve the identification of bone, soft tissue, and air in brain MRI scans. By combining standard deep learning techniques with specialized mathematical filters, the researchers achieved more accurate bone segmentation, which is vital for PET scan corrections.

Keywords:
CNNContourletMRSegmentationShearletDeep Convolutional Neural NetworksMedical Image ProcessingNon Subsampled ShearletPseudo Computed Tomography

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Area of Science:

  • Medical imaging diagnostics within radiology
  • Deep learning applications in neuroimaging research
  • Computational neuroscience and multiresolution handcrafted features analysis

Background:

No prior work had resolved the persistent difficulty of accurately identifying bone tissue within brain magnetic resonance imaging scans. This limitation hinders the generation of reliable pseudo computed tomography images for positron emission tomography attenuation correction. Deep convolutional neural networks have become standard tools for automated image segmentation tasks in medical settings. However, these models sometimes struggle to capture specific directional properties required for precise tissue classification. That uncertainty drove the development of hybrid architectures that integrate diverse feature sets. Prior research has shown that combining different data representations can often enhance model performance. This gap motivated the exploration of multiresolution analysis to augment existing deep learning frameworks. Researchers sought to determine if adding handcrafted features could improve segmentation accuracy for complex anatomical structures.

Purpose Of The Study:

The researchers aim to develop a robust segmentation approach that combines multiresolution handcrafted features with deep learning. This work addresses the persistent difficulty of accurately identifying bone tissue within brain magnetic resonance images. Precise bone segmentation is a vital requirement for creating pseudo computed tomography images used in positron emission tomography attenuation correction. The authors seek to add directional properties to standard convolutional neural network features to enrich the classification process. They intend to segment the brain into three distinct tissue classes: bone, soft tissue, and air. By integrating non subsampled Contourlet and Shearlet coefficients, the team hopes to improve overall segmentation performance. The study also explores using entropy values to reduce input dimensionality while maintaining high accuracy. This investigation seeks to provide a more efficient and reliable method for medical image analysis.

Main Methods:

The investigators designed a hybrid framework that fuses deep learning with mathematical multiresolution analysis. They employed non subsampled Contourlet and Shearlet transforms to extract directional information from the input images. These handcrafted descriptors were then concatenated with features generated by a convolutional neural network. The team applied entropy-based selection to filter out redundant coefficients and lower the input dimensionality. Validation involved fifty clinical brain magnetic resonance and computed tomography image pairs. The researchers calculated precision, recall, Dice similarity coefficient, and Jaccard similarity coefficient to assess performance. They benchmarked their hybrid approach against various alternative methods previously described in scientific literature. This systematic evaluation ensured a robust comparison of the proposed model against standard segmentation techniques.

Main Results:

The hybrid model achieved a significant improvement in bone tissue segmentation accuracy compared to baseline approaches. Specifically, the Dice similarity coefficient for the bone class increased from 0.6179 to 0.6416. The researchers found that non subsampled Shearlet coefficients provided more useful information than non subsampled Contourlet coefficients. This finding highlights the importance of selecting appropriate directional features for complex tissue classification. The integration of these multiresolution descriptors consistently enriched the feature set used by the convolutional neural network. All performance metrics, including precision and recall, reflected the enhanced capability of the hybrid architecture. The study successfully demonstrated the utility of combining handcrafted features with deep learning for brain tissue segmentation. These results confirm that the proposed mechanism effectively addresses the challenges of identifying bone in magnetic resonance images.

Conclusions:

The authors propose that integrating multiresolution coefficients with deep learning features enhances the segmentation of brain tissues. Their synthesis suggests that combining non subsampled Shearlet coefficients with convolutional neural network outputs yields superior results. The researchers observed that these specific directional features provide more informative data than non subsampled Contourlet coefficients. This study demonstrates that augmenting standard neural network inputs with handcrafted mathematical descriptors improves bone tissue identification. The findings imply that such hybrid approaches are effective for creating pseudo computed tomography images. These results support the use of dimensionality reduction techniques like entropy calculation to optimize model efficiency. The authors conclude that their proposed method outperforms several existing techniques reported in the literature. This work highlights the potential of multiresolution analysis in refining medical image segmentation for clinical applications.

The researchers propose a hybrid architecture that merges non subsampled Shearlet and Contourlet coefficients with deep learning features. This combination adds directional properties to the model, which helps distinguish bone, soft tissue, and air more effectively than using convolutional neural networks alone.

The authors utilize entropy values to evaluate and select the most informative coefficients from the multiresolution filters. This process reduces the overall input dimensionality, ensuring the model remains computationally efficient while focusing on the most relevant image data.

The authors state that non subsampled Shearlet coefficients are necessary because they provide more useful information for tissue classification than the non subsampled Contourlet counterparts. This distinction allows the model to better capture the complex directional structures found in brain anatomy.

The researchers use these coefficients as a secondary data source to augment the features extracted by the convolutional neural network. This integration enriches the input set, allowing the model to leverage both learned and handcrafted representations for improved accuracy.

The team measured performance using precision, recall, Dice similarity coefficient, and Jaccard similarity coefficient. They specifically observed an improvement in the Dice similarity coefficient for the bone class, which rose from 0.6179 to 0.6416.

The authors claim that their hybrid method offers a more precise bone segmentation compared to existing techniques. They propose that this improvement is vital for generating accurate pseudo computed tomography images, which are required for positron emission tomography attenuation correction.