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Updated: Aug 28, 2025
Non-invasive Parenchymal, Vascular and Metabolic High-frequency Ultrasound and Photoacoustic Rat Deep Brain Imaging
Published on: March 2, 2015
Transfontanelle photoacoustic imaging for in-vivo cerebral oxygenation measurement
Rayyan Manwar1, Laura S McGuire2, Md Tarikul Islam1
1Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA.
Abstract:
The capability of photoacoustic (PA) imaging to measure oxygen saturation through a fontanelle has been demonstrated in large animals in-vivo. We called this method, transfontanelle photoacoustic imaging (TFPAI). A surgically induced 2.5 cm diameter cranial window was created in an adult sheep skull to model the human anterior fontanelle. The performance of the TFPAI has been evaluated by comparing the PA-based predicted results against the gold standard of blood gas analyzer measurements.
