Biosynthesis of zinc oxide nanoparticles via endophyte Trichoderma viride and evaluation of their antimicrobial and...

The biogenic method for synthesis of nanoparticles is preferred over the traditional strategies, on account of its ease, environmental friendliness, and cost-effectivity, wherein fungi endorse themselves to be the most appropriate precursor for the same. In recent times numerous metal nanoparticles have been reported to exhibit significant therapeutic activities, out of which Zinc Oxide nanoparticles (ZnO NPs) stand apart on account of their multidimensional nature. Thus, this study was carried out with an aim to biosynthesize ZnO NPs utilizing endophyte Trichoderma viride, isolated from the seeds of Momordica charantia. The physicochemical characterization of NPs was done via employing a combination of spectroscopic and microscopic techniques. The NPs were found to have a hexagonal shape and possessed an average particle size of around 63.3 nm. The antimicrobial activity of NPs was evaluated against multi-drug resistant organisms and it was observed to be an appreciable one whereas the antioxidant activity was deduced to be dose-dependent. Thus, these ZnO NPs can be considered as a probable active ingredient of any future therapeutic conceptualization after undertaking a thorough toxicological assessment.