From selective testing to actionable prevention: The VALOR-ED pathway

Broul and colleagues provide a timely high-value approach to laboratory testing in erectile dysfunction and suspected hypogonadism. We extend their analysis by proposing VALOR-ED, a five-component pathway that links phenotype verification, analytical fitness, cardiometabolic risk, selective reflex testing, and actionable reporting. The framework addresses assay variability, borderline biochemical results, diagnostic inequity, and the frequent disconnect between laboratory testing and preventive care. Multicentre validation across diverse laboratory platforms and health systems could establish an internationally applicable benchmark for clinically actionable and equitable testing.