Related Experiment Video
Updated: Aug 28, 2025
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
11.6K
Association between periodontitis and heart failure in the general population
Carolin Walther1, Jan-Per Wenzel2,3,4, Renate B Schnabel2,4,5
1Department of Periodontics, Preventive and Restorative Dentistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ESC Heart Failure
|September 14, 2022
Summary
Severe periodontitis is linked to heart failure with mid-range and reduced ejection fraction (HF(m)rEF). This study highlights a potential connection between severe gum disease and specific cardiac conditions, suggesting a need for integrated medical and dental care.
Area of Science:
- Cardiology
- Periodontology
- Public Health
Background:
- Limited data exists on the association between periodontitis and preclinical cardiac alterations.
- Periodontitis, a severe gum disease, may impact cardiovascular health.
- Understanding this link is crucial for early detection and prevention of heart conditions.
Purpose of the Study:
- To investigate the association between periodontitis and cardiac changes using transthoracic echocardiography.
- To determine if periodontitis is linked to different heart failure (HF) phenotypes, including HF with preserved ejection fraction (HFpEF) and HF with mid-range and reduced ejection fraction (HF(m)rEF).
Main Methods:
- Utilized data from the population-based Hamburg City Health Study, including 6209 participants with periodontal screening and transthoracic echocardiography.
- Classified periodontitis severity (none/mild, moderate, severe) and heart failure phenotypes according to 2021 ESC HF guidelines.
- Performed statistical analysis, adjusting for multiple cardiovascular risk factors to assess the association between periodontitis and HF phenotypes.
Main Results:
- Severe periodontitis was significantly associated with HF(m)rEF (OR: 3.16; 95% CI: 1.21, 8.22; P=0.019) after adjusting for confounders.
- No significant association was found between periodontitis and HFpEF or HF in general.
- Participants with severe periodontitis exhibited a higher burden of cardiovascular risk factors.
Conclusions:
- Severe periodontitis is significantly associated with HF(m)rEF, suggesting a potential link between severe gum disease and this specific type of heart failure.
- The findings indicate that individuals with severe periodontitis may require closer monitoring for cardiac health.
- Further research is needed to explore the role of systemic inflammation as a potential mediator between periodontitis and heart failure.
Related Concept Videos
01:27Heart Failure I: Introduction
45
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
45
01:17Pathophysiology of Heart Failure
1.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.8K
01:30Heart Failure IV: Classification and Diagnostic Evaluation
27
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
27
01:23Rheumatic Heart Disease I: Introduction
32
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
32
01:29Heart Failure II: Pathophysiology
31
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
31
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
46
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
46