Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Situ Oxygen Shuttling within a Bilayer Electrified Membrane Enables Aeration-Free Electro-Fenton Water Purification.

ACS nano·2026
Same author

Interfacial Polycondensation Kinetics Regulation Enables Microporous Polyesteramide Membranes for Ultraselective Water Purification.

Environmental science & technology·2026
Same author

Glycosphingolipids regulate phosphatidylserine transport machinery that operates at ER-PM contact sites.

Nature communications·2026
Same author

Association between the prognostic nutritional index and prognosis in patients with non-small cell lung cancer undergoing curative lung resection: a systematic review and meta-analysis.

Frontiers in oncology·2026
Same author

Personalized Digital Health Solutions to Increasing Diabetes-Related Knowledge and Behavioral Outcomes: Results From a Randomized Controlled Trial.

JMIR diabetes·2026
Same author

Aberrant CD4<sup>+</sup> T cell refeeding response impairs neuro-immune crosstalk in Parkinson's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Releasing the neuronal brake: Inhibiting AhR to enhance axon regeneration.

Clinical and translational medicine·2026
Same journal

Correction to "[NSUN2 promotes colorectal cancer progression and increases lapatinib sensitivity by enhancing CUL4B/ErbB-STAT3 signalling in a non-m5C manner]".

Clinical and translational medicine·2026
Same journal

USP43-mediated deubiquitination of SLC7A11 protects against LPS-induced acute lung injury by inhibiting ferroptosis.

Clinical and translational medicine·2026
Same journal

Tumour-macrophage crosstalk initiated by NFIC/METTL3 negative feedback loop via exosomal miR-194-5p promotes NSCLC progression.

Clinical and translational medicine·2026
Same journal

α7nAChR agonist GTS-21 ameliorates sepsis-induced acute kidney injury via MEF2/PGC-1α/HO-1 axis in mice.

Clinical and translational medicine·2026
Same journal

A living biobank of sarcoma patient-derived cell cultures reveals multi-omic and functional insights that capture disease heterogeneity.

Clinical and translational medicine·2026
See all related articles

Related Experiment Video

Updated: Aug 28, 2025

In vivo Optogenetic Stimulation of the Rodent Central Nervous System
09:37

In vivo Optogenetic Stimulation of the Rodent Central Nervous System

Published on: January 15, 2015

59.5K

Nano-optogenetic immunotherapy.

Kai Huang1, Xiaoxuan Liu2, Gang Han1

  • 1Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.

Clinical and Translational Medicine
|September 14, 2022
PubMed
Summary
This summary is machine-generated.

Chimeric antigen receptor (CAR) T cell therapy shows promise for cancer treatment but faces safety concerns like "on-target off-tumour" effects. New approaches using nanotechnology and optogenetics aim for precise, controllable CAR T cell activation to improve safety and efficacy.

Keywords:
CAR T cellbiophotonicscancerimmunotherapynanotechnologyoptogenetics

More Related Videos

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits
09:17

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits

Published on: March 14, 2018

10.3K
Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
14:40

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

Published on: October 27, 2020

18.5K

Related Experiment Videos

Last Updated: Aug 28, 2025

In vivo Optogenetic Stimulation of the Rodent Central Nervous System
09:37

In vivo Optogenetic Stimulation of the Rodent Central Nervous System

Published on: January 15, 2015

59.5K
Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits
09:17

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits

Published on: March 14, 2018

10.3K
Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
14:40

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

Published on: October 27, 2020

18.5K

Area of Science:

  • Immunotherapy
  • Oncology
  • Biotechnology

Background:

  • Chimeric antigen receptor (CAR) T cell therapy is a rapidly advancing cancer treatment, with six FDA-approved products for hematologic malignancies.
  • CAR T cells genetically engineered to target cancer cells have shown remarkable efficacy in clinical trials for various cancers.
  • Significant safety challenges persist, including "on-target off-tumour" toxicity and severe systemic inflammation (cytokine release syndrome, neurotoxicity).

Purpose of the Study:

  • To address the safety limitations of current CAR T cell immunotherapies.
  • To explore the integration of nanotechnology and optogenetics for enhanced control over CAR T cell activity.
  • To develop spatiotemporally-controllable CAR T cells for precise, personalized cancer therapy.

Main Methods:

  • Review of current CAR T cell therapy applications and limitations.
  • Discussion of integrating nanotechnology and optogenetics into CAR T cell design.
  • Conceptual framework for wireless, photo-tunable CAR T cell activation.

Main Results:

  • CAR T cell therapy has achieved significant cancer remission but is hampered by safety concerns.
  • The proposed combination of nanotechnology and optogenetics offers a potential solution for precise control.
  • Spatiotemporally-controllable CAR T cells could enable targeted therapy within the tumour microenvironment.

Conclusions:

  • CAR T cell immunotherapy requires advanced control mechanisms to mitigate safety risks.
  • Optogenetically and nanotechnologically enhanced CAR T cells offer a promising avenue for safer, more effective cancer treatment.
  • Future research should focus on developing wireless, photo-tunable immune cell activation for personalized cancer therapy.