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The importance of phenoconversion when using the CYP2D6 genotype in clinical practice
Emily J Cicali1,2, Kristin Wiisanen1,2
1Department of Pharmacotherapy & Translational Research, University of Florida, College of Pharmacy, Gainesville, FL 32608, USA.
Pharmacogenomics
|September 14, 2022
Summary
Clinical phenoconversion is crucial for interpreting CYP2D6 results in patient care. This article explains how to incorporate phenoconversion using manual methods or online tools.
Area of Science:
- Pharmacogenomics
- Clinical Pharmacology
Background:
- Interpreting cytochrome P450 2D6 (CYP2D6) genetic test results requires consideration of clinical phenoconversion.
- Phenoconversion, the process by which an individual's phenotype changes over time, impacts drug metabolism and response.
Discussion:
- This article details methodologies for integrating phenoconversion into the clinical interpretation of CYP2D6 pharmacogenetic data.
- Both manual assessment and the use of available online tools and resources are discussed as practical approaches.
Key Insights:
- Clinical phenoconversion is a vital factor often overlooked in standard CYP2D6 pharmacogenetic testing.
- Accurate interpretation of CYP2D6 results necessitates accounting for phenoconversion to predict drug efficacy and toxicity.
Outlook:
- Future clinical practice should routinely incorporate phenoconversion assessments alongside genetic data for personalized medicine.
- Development and accessibility of user-friendly tools will enhance the clinical adoption of phenoconversion in pharmacogenomics.
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