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Updated: Aug 28, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Controlling Superselectivity of Multivalent Interactions with Cofactors and Competitors

Tine Curk1, Galina V Dubacheva2, Alain R Brisson3

  • 1Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, United States.

Journal of the American Chemical Society
|September 14, 2022
PubMed
Summary

Cofactors and competitors modulate multivalent binding interactions by simply rescaling individual bond affinities. This theoretical model explains superselectivity in biological recognition and nanomedicine applications.

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