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Updated: Aug 28, 2025

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Monkeypox in Patient Immunized with ACAM2000 Smallpox Vaccine During 2022 Outbreak
Emerging Infectious Diseases
|September 14, 2022
Abstract:
We report a case of monkeypox in the United States in a patient who had been vaccinated with ACAM2000 smallpox vaccine 8 years earlier. Despite his vaccination status, he still contracted disease. He showed prodromal symptoms preceding development of painless penile lesions that later coalesced.
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