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[Androgenic status in men during COVID-19]
R V Rozhivanov1, G A Melnichenko1, E N Andreeva1
1Endocrinology Research Centre.
Problemy Endokrinologii
|September 15, 2022
Summary
COVID-19 significantly impacts male testosterone levels, causing hypogonadism in 87% of patients. Hormone levels improved significantly after treatment, resolving hypogonadism in 40%, especially in younger individuals.
Area of Science:
- Endocrinology
- Virology
- Men's Health
Background:
- COVID-19 negatively affects the male reproductive system.
- Androgenic status in men with COVID-19 requires investigation.
Purpose of the Study:
- To evaluate total testosterone, sex hormone-binding globulin (SHBG), and free testosterone levels in men during acute COVID-19 and convalescence.
Main Methods:
- Prospective study of 70 men with moderate to severe COVID-19.
- Measured total testosterone and SHBG, calculated free testosterone.
- Data collected at hospitalization and discharge.
Main Results:
- 87% of patients presented with hypogonadism upon hospitalization.
- Inpatient treatment significantly increased total testosterone, SHBG, and free testosterone (p<0.001).
- Hypogonadism resolved in 40% of patients post-treatment.
Conclusions:
- COVID-19 adversely affects testosterone production, causing reversible hypogonadism.
- Younger patients demonstrate better reversibility of COVID-19-induced hypogonadism.
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