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Excessive Daytime Sleepiness in Parkinson's Disease
Hanshu Liu1, Jingwen Li1, Xinyi Wang1
1Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Nature and Science of Sleep
|September 15, 2022
Summary
Excessive daytime sleepiness (EDS) is common in Parkinson's disease (PD). This review clarifies its prevalence, drug effects, and highlights neurodegeneration in wake-promoting nuclei as a key cause.
Area of Science:
- Neurology
- Sleep Medicine
- Neuroscience
Background:
- Excessive daytime sleepiness (EDS) is a prevalent and debilitating sleep disorder in Parkinson's disease (PD).
- It significantly impacts patient quality of life, increases accident risk, and presents diagnostic and therapeutic challenges.
- Understanding the underlying mechanisms and epidemiological variations of EDS in PD is crucial.
Purpose of the Study:
- To review the epidemiology of EDS in PD, addressing discrepancies between subjective and objective measures.
- To analyze the impact of antiparkinsonian drugs on EDS and elucidate their pharmacological mechanisms.
- To highlight the neurodegenerative basis of EDS in PD, focusing on wake-promoting nuclei and neurotransmitter systems.
Main Methods:
- Comprehensive literature review of studies on EDS in Parkinson's disease.
- Analysis of epidemiological data, including subjective and objective sleep measures.
- Examination of pharmacological effects of antiparkinsonian drugs on EDS.
Main Results:
- Inconsistent prevalence rates of EDS in PD are noted, influenced by measurement methods.
- Common antiparkinsonian drugs exhibit varied effects on EDS, necessitating careful clinical selection.
- Degeneration of wake-promoting nuclei is identified as a primary pathological mechanism for EDS in PD.
Conclusions:
- EDS in PD is multifactorial, influenced by disease progression and medication.
- Targeting neurodegenerative changes in wake-promoting pathways offers potential for novel EDS interventions in PD.
- Further research into sleep-wake cycle alterations is essential for developing effective treatments.
Keywords:
Parkinson’s diseasedopaminergic agentsdopaminergic neuronsepidemiologyexcessive daytime sleepinesswakefulnessMore Related Videos
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