Related Experiment Video
Updated: Aug 28, 2025
02:28
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
483
Psoriasis and medical ramifications: A comprehensive analysis based on observational meta-analyses
Yun Zhou1,2, Lixian Zhong1, Lianli Shen1
1Department of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Frontiers in Medicine
|September 15, 2022
Summary
Psoriasis is linked to 69 health outcomes, with high-quality evidence for 8 conditions including ulcerative colitis and multiple sclerosis. This study found no benefits of psoriasis for any medical endpoint.
Area of Science:
- Dermatology
- Epidemiology
- Public Health
Background:
- Psoriasis is a chronic inflammatory disease with known associations with various comorbidities.
- Previous systematic reviews and meta-analyses have explored these links, but a comprehensive assessment of evidence strength is needed.
Purpose of the Study:
- To comprehensively analyze the strength and evidence for associations between psoriasis and medical end-point ramifications.
- To evaluate the quality of epidemiological evidence for psoriasis-related health outcomes.
Main Methods:
- A systematic search of three databases for meta-analyses linking psoriasis and medical outcomes.
- Recalculation of effect sizes, confidence intervals, and heterogeneity; assessment of methodological quality using AMSTAR 2.
- Grading of epidemiological evidence and performance of subgroup analyses based on psoriasis severity and study design.
Main Results:
- Included 38 articles with 85 unique meta-analyses, identifying 69 statistically significant outcomes associated with psoriasis.
- Only 8 outcomes demonstrated high-quality epidemiological evidence: nonvascular dementia, ulcerative colitis, pediatric dyslipidemia, gestational diabetes, gestational hypertension, fracture, multiple sclerosis, and schizophrenia.
Conclusions:
- Psoriasis is associated with an increased risk of 69 health outcomes, with robust evidence for 8 specific conditions.
- No evidence suggests psoriasis confers benefits for any medical endpoint.
- Further large-scale, multi-center prospective cohort studies are recommended to validate these findings.
Related Concept Videos
01:23Skin Diseases and Disorders
4.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.0K
01:11Genome-wide Association Studies-GWAS
14.0K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.0K
01:26Nephrotic Syndrome II : Assessment and Medical Management
17
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
17
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
162
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
162
01:14Changes in Skin Color: Clinical Perspectives
2.1K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.1K
01:20The JAK-STAT Signaling Pathway
9.2K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.2K