Related Experiment Video
Updated: Aug 28, 2025
17:06
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
26.4K
Relating Cognition to both Brain Structure and Function: A Systematic Review of Methods.
Marta Czime Litwińczuk1, Nelson Trujillo-Barreto1, Nils Muhlert1
1Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Brain Connectivity
|September 15, 2022
Summary
This review examines how structural and functional neuroimaging data are integrated to understand brain mechanisms of cognition. Few studies formally integrate both, highlighting a need for advanced quantitative approaches.
Area of Science:
- Cognitive neuroscience
- Neuroimaging
- Brain structure and function
Background:
- Cognitive neuroscience investigates cognition through brain structure and function.
- Integrating structural and functional neuroimaging is key to understanding cognition.
- This review systematically assesses the integration of these methods.
Approach:
- Searched Web of Science and Scopus for studies on healthy adults with cognitive and neuroimaging data.
- Included studies that collected structural and functional neuroimaging data.
- Analyzed the integration of structural and functional data in relation to cognitive performance.
Key Points:
- Only 5% of screened studies met inclusion criteria.
- 50% related cognition to structure/function without quantitative analysis.
- 31% formally integrated structural and functional brain data.
- Four emergent quantitative approaches identified: comparative, predictive, fusion, and complementary.
Conclusions:
- Most studies examine either brain structure or function, rarely integrating both.
- Identified four approaches to quantitatively analyze the structure-function-cognition relationship.
- Discusses insights from each approach and guidance for selecting methods based on research questions.
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