Fentanyl in Pressed Oxycodone Pills: A Qualitative Analysis of Online Community Experiences with an Emerging Drug

Simran Arya1,2, Suhas Nagappala2,3, Noa Krawczyk2

  • 1Renaissance School of Medicine at Stony, Brook University, Stony Brook, NY.

Substance Use & Misuse
|September 15, 2022
PubMed
Abstract

Insights

Fentanyl-laced oxycodone pills (M30s) are a growing concern. Many Reddit users discussed concerns about M30 pill contamination, anxiety over their composition, and strategies for harm reduction.

Area of Science:

  • Public Health
  • Social Science
  • Digital Health

Background:

  • The prevalence of fentanyl-contaminated oxycodone pills, known as M30s, is a significant public health issue.
  • Understanding user perceptions and experiences with these contaminated pills is crucial for developing effective interventions.

Purpose of the Study:

  • To examine Reddit content to understand perceptions and experiences with fentanyl-contaminated M30 pills.
  • To identify themes related to awareness, anxiety, and harm reduction strategies among users.

Main Methods:

  • Analysis of 71 drug-related subreddits using 34 fentanyl-related search terms from January 1, 2021, to July 28, 2021.
  • Thematic analysis of a random subsample of 500 posts, with 226 relevant posts included.

Main Results:

  • Over one-third of posts mentioning fentanyl related to pressed M30 pills.
  • Pervasive suspicion of contamination (51.2%), anxiety over pill composition (40%), and discussion of mitigation/testing strategies (29.4%) were identified.

Conclusions:

  • Reddit users are aware of fentanyl contamination in the pressed pill market.
  • Online communities provide a platform for discussing harm reduction and anxieties related to fentanyl exposure.

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
399
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
342
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
763
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
1.6K
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
835
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
629