Related Experiment Video
Updated: Aug 28, 2025
08:50
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
3.8K
Preterm Birth Therapies to Target Inflammation.
Ioannis Pavlidis1, Sarah J Stock2
1University of Warwick Biomedical Research Unit in Reproductive Health, Coventry, UK.
Journal of Clinical Pharmacology
|September 15, 2022
Summary
Preterm birth (PTB) prevention and treatment remain challenging due to limited therapies. Targeting inflammation in gestational tissues offers promising new strategies for managing PTB and its complications.
Area of Science:
- Reproductive biology
- Immunology
- Perinatology
Background:
- Preterm birth (PTB) is a leading cause of infant mortality.
- Limited therapeutic options exist for PTB prevention and treatment.
- Inflammation in gestational tissues is a key factor in PTB pathophysiology.
Purpose of the Study:
- To review current and emerging therapeutic strategies for PTB.
- To discuss therapies targeting inflammatory pathways involved in PTB.
Main Methods:
- Review of traditional therapies for PTB.
- Highlighting novel preclinical approaches targeting inflammatory mediators.
- Discussion of mechanistic studies on PTB pathophysiology.
Main Results:
- Inflammation, even without infection, can trigger parturition.
- Several therapeutic targets within inflammatory pathways have been identified.
- Both established and novel therapeutic approaches show potential.
Conclusions:
- Effective PTB prevention and treatment strategies are urgently needed.
- Targeting inflammation offers a promising avenue for PTB management.
- Collaborative efforts are essential to address the challenge of PTB.
Related Concept Videos
01:29Inflammatory Bowel Disease IV: Pharmacological Management
174
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
174
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
215
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
215
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
256
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
256
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
192
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
192
01:28Inflammatory Response
5.3K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
5.3K
01:22Methods of reducing fever
732
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
732