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[Phage therapy of purulent-inflammatory pathology of the outer and middle ear]

A V Gurov1, E G Lapenko1, A I Kryukov1

  • 1Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow, Russia.

Vestnik Otorinolaringologii
|September 15, 2022
PubMed

Insights

Bacteriophage therapy offers a promising alternative to antibiotics for treating antibiotic-resistant bacterial infections, particularly in ear diseases. This review highlights research on using bacteriophages and their enzymes to combat multi-resistant pathogens in the outer and middle ear.

Area of Science:

  • Microbiology
  • Otolaryngology
  • Infectious Diseases

Background:

  • Antibiotic resistance is a growing global health concern, necessitating alternative antimicrobial strategies.
  • Phage therapy, using bacteriophages to target bacteria, is an established treatment in otorhinolaryngology for conditions like rhinosinusitis.
  • The application of bacteriophage therapy for inflammatory ear diseases remains underexplored.

Purpose of the Study:

  • To review current research on bacteriophage preparations for treating inflammatory ear diseases.
  • To highlight in vitro microbiological studies targeting multi-resistant bacterial pathogens in the outer and middle ear.

Main Methods:

  • Literature review of recent scientific works on bacteriophage therapy for ear infections.
  • Analysis of in vitro microbiological studies investigating bacteriophages and their enzymes (lysins) against resistant bacteria.

Main Results:

  • Ongoing global research focuses on identifying effective bacteriophages and their enzymes against antibiotic-resistant bacteria.
  • Studies explore genetic modifications to restore bacterial sensitivity to antimicrobial drugs.
  • In vitro data indicate potential for bacteriophages in combating multi-resistant pathogens in ear infections.

Conclusions:

  • Bacteriophage therapy presents a viable alternative for managing antibiotic-resistant bacterial infections in otorhinolaryngology, especially for ear diseases.
  • Further research and clinical trials are warranted to establish the efficacy and safety of phage preparations for treating inflammatory ear conditions.
Keywords:
bacteriophagesotitisphage therapy

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