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Updated: Aug 28, 2025

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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Genomic Insights into Non-steroidal Nuclear Receptors in Prostate and Breast Cancer

Sajad A Wani1, Moray J Campbell2

  • 1Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA.

Advances in Experimental Medicine and Biology
|September 15, 2022
PubMed

Insights

Alterations in transcriptional programs are key in prostate and breast cancer, affecting androgen receptor (AR) and estrogen receptor alpha (ERα) functions. Understanding interactions with understudied Type II nuclear receptors offers new insights into cancer biology.

Area of Science:

  • Oncology
  • Molecular Biology
  • Endocrinology

Background:

  • Transcriptional program alterations are fundamental in prostate cancer (PCa) and breast cancer (BrCa).
  • Steroidal nuclear receptors (NRs), androgen receptor (AR) and estrogen receptor alpha (ERα), are central to PCa and mammary gland biology.
  • Genomic interactions of AR and ERα are distorted by functional interplay with understudied non-steroidal Type II NRs.

Purpose of the Study:

  • To review the roles and interactions of Type II NRs in PCa and BrCa.
  • To highlight the convergence and functional consequences of Type II NR cistromes in cancer.

Main Methods:

  • Review of existing literature on Type II NR cistromes in PCa and BrCa.
  • Analysis of genomic interactions between steroidal and non-steroidal NRs.

Main Results:

  • AR cistromes overlap with those of various Type II NRs, indicating integrated functions.
  • Studies reveal convergence and functional consequences of Type II NR cistromes (HNF4s, RARs, PPARs, VDR) in PCa and BrCa.

Conclusions:

  • Interactions between steroidal and Type II NRs significantly influence transcriptional regulation in cancer.
  • Further research into Type II NRs is crucial for understanding and targeting PCa and BrCa.
Keywords:
BookmarkingBreast cancerCistromeEpigeneticsNon-steroidal nuclear receptorsProstate cancerTranscriptome

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