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COVID-19 and Kidney Disease
Maureen Brogan1, Michael J Ross1,2
1Division of Nephrology, Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA;
Annual Review of Medicine
|September 15, 2022
Summary
COVID-19 can harm kidneys, causing acute injury and worsening chronic kidney disease. Patients with severe kidney disease face higher mortality and require careful COVID-19 treatment adjustments.
Area of Science:
- Nephrology
- Infectious Diseases
- Virology
Background:
- COVID-19 is linked to acute kidney injury (AKI) and can worsen chronic kidney diseases (CKDs).
- While SARS-CoV-2 kidney cell infection is reported, its causal role in kidney disease remains uncertain.
- Impaired renal perfusion and immune dysregulation are key drivers of kidney injury in COVID-19 patients.
Purpose of the Study:
- To review the impact of COVID-19 on kidney health.
- To discuss the challenges in managing COVID-19 in patients with pre-existing kidney conditions.
- To highlight the need for tailored therapeutic strategies for this vulnerable population.
Main Methods:
- Literature review and synthesis of existing research on COVID-19 and kidney disease.
- Analysis of clinical data regarding COVID-19 outcomes in patients with varying degrees of kidney function.
- Examination of pharmacological considerations for treating COVID-19 in individuals with kidney impairment.
Main Results:
- Patients with chronic kidney disease, particularly those on kidney replacement therapy or post-transplant, exhibit significantly higher COVID-19 mortality.
- Exclusion of severe kidney disease patients from clinical trials necessitates extrapolation of treatment protocols.
- Specific COVID-19 medications require dose adjustments or avoidance in patients with compromised kidney function.
Conclusions:
- COVID-19 poses a significant threat to individuals with kidney disease, increasing mortality risk.
- Current therapeutic guidelines for COVID-19 may not be optimal for patients with kidney conditions.
- Further research is crucial to establish effective prevention and treatment strategies for COVID-19 in the context of kidney disease.
Keywords:
COVID-19ESKDKFRTSARS-CoV-2chronic kidney diseasedialysisend-stage kidney diseasekidneykidney failure requiring replacement therapykidney transplantMore Related Videos
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