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Updated: Aug 28, 2025

Detecting and Characterizing Protein Self-Assembly In Vivo by Flow Cytometry
Published on: July 17, 2019
Contact-mediated signaling enables disorder-driven transitions in cellular assemblies
Chandrashekar Kuyyamudi1,2, Shakti N Menon1, Sitabhra Sinha1,2
1The Institute of Mathematical Sciences, CIT Campus, Taramani, Chennai 600113, India.
Abstract:
We show that, when cells communicate by contact-mediated interactions, heterogeneity in cell shapes and sizes leads to qualitatively distinct collective behavior in the tissue. For intercellular coupling that implements lateral inhibition, such disorder-driven transitions can substantially alter the asymptotic pattern of differentiated cells by modulating their fate choice through changes in the neighborhood geometry. In addition, when contact-induced signals influence inherent cellular oscillations, disorder leads to the emergence of functionally relevant partially-ordered dynamical states.
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