Maternal testosterone affects offspring telomerase activity in a long-lived seabird

Area of Science:

• Endocrinology
• Developmental Biology
• Ecology

Background:

• Androgens, like testosterone, are implicated in intergenerational plasticity.
• Maternal testosterone in eggs influences offspring traits, but mechanisms are unclear.
• Telomerase, crucial for telomere maintenance, is a target of androgen signaling.

Purpose of the Study:

• Investigate the effect of maternal testosterone on offspring telomerase levels in a natural population.
• Examine the consequences of maternal testosterone on offspring telomere length and growth.
• Elucidate the role of maternal testosterone in intergenerational plasticity.

Main Methods:

• Experimental manipulation of egg testosterone levels in yellow-legged gulls (Larus michahellis).
• Measurement of offspring telomerase activity and telomere length.
• Monitoring of chick growth rates during the first week of life.

Main Results:

• Chicks from testosterone-treated eggs showed higher average telomerase levels.
• Testosterone-treated chicks exhibited faster growth rates in the first week.
• A trend for longer telomeres at hatching in treated chicks, which diminished by day 6.

Conclusions:

• Maternal testosterone may promote offspring growth and telomerase levels, suggesting adaptive value.
• Telomerase has functions beyond telomere maintenance, potentially influencing stress resistance and tissue genesis.
• Further research is needed to understand the link between maternal hormones, offspring telomerase, and fitness.