Related Experiment Video

Updated: Aug 28, 2025

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

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The association between comorbidities and coronavirus disease 2019 hospitalization among people with HIV differs by

Caitlin A Moran1,2, Nora T Oliver1,3, Brittany Szabo2

  • 1Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine.

AIDS (London, England)
|September 16, 2022
PubMed

Insights

Comorbidity burden significantly increases COVID-19 hospitalization risk in older people with HIV (PWH). Younger PWH hospitalized were more likely to not be on antiretroviral therapy (ART).

Area of Science:

  • Infectious Diseases
  • Public Health
  • Epidemiology

Background:

  • People with HIV (PWH) may face unique risks for severe outcomes from COVID-19.
  • Understanding factors associated with COVID-19 hospitalization in PWH is crucial for targeted interventions.
  • Age may influence the clinical presentation and risk factors for COVID-19 in PWH.

Purpose of the Study:

  • To investigate whether factors linked to COVID-19 hospitalization differ between younger and older people with HIV (PWH).
  • To identify demographic and clinical predictors of SARS-CoV-2 infection hospitalization in PWH, stratified by age.

Main Methods:

  • A retrospective cohort study included adult PWH with positive SARS-CoV-2 PCR tests.
  • Data were collected from a public safety-net health system and a Veterans Affairs Medical Center in Atlanta, Georgia.
  • Multivariable logistic regression analyzed factors associated with COVID-19 hospitalization, stratified by age (<50 and ≥50 years).

Main Results:

  • Overall, older age, heart disease, and history of hepatitis C virus (HCV) were associated with COVID-19 hospitalization.
  • In PWH under 50, older age and lack of antiretroviral therapy (ART) were linked to hospitalization.
  • In PWH aged 50 and older, older age, heart disease, HCV history, and comorbidity burden were associated with hospitalization.

Conclusions:

  • Comorbidity burden is a stronger predictor of COVID-19 hospitalization in older PWH compared to younger PWH.
  • Lack of ART is a critical risk factor for hospitalization in younger PWH.
  • Findings inform risk stratification for COVID-19 therapies and booster recommendations in PWH.
Abstract

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