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[Clinical features and epidemiological significance of pertussis in infants]
Kai-Hu Yao1, Ya-Hong Hu1, Lin Yuan1
1National Center for Children's Health/Beijing Children's Hospital, Capital Medical University/Laboratory of Microbiology, Beijing Pediatric Research Institute/National Key Discipline of Pediatrics (Capital Medical University)/Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing 100045, China.
Insights
Infantile pertussis indicates ongoing community pertussis transmission. Preventing infant pertussis through early diagnosis, treatment, and contact management is crucial for controlling pertussis spread.
Area of Science:
- Public Health
- Infectious Diseases
- Pediatrics
Background:
- Infantile pertussis signifies persistent pertussis transmission within communities.
- Infants are highly susceptible to pertussis and act as key transmission hubs.
Purpose of the Study:
- To underscore the critical importance of preventing infantile pertussis.
- To highlight the need for enhanced awareness and diagnostic measures for pertussis in infants.
Main Methods:
- Review of pertussis transmission dynamics in communities.
- Emphasis on clinical identification, diagnosis, and treatment of infantile pertussis.
- Management strategies for close contacts of infected infants.
Main Results:
- Infantile pertussis is a marker for sustained community pertussis.
- Reported cases may underestimate the true incidence of pertussis in infants.
- Effective management of infant cases and contacts can disrupt transmission.
Conclusions:
- Preventing infantile pertussis is central to overall pertussis control strategies, including vaccination.
- Clinical awareness, prompt diagnosis, and management of close contacts are essential to block community spread.
Abstract:
Infantile pertussis is clear evidence for the persistent transmission of pertussis in communities. Infants are the most vulnerable population for pertussis infection and are also important nodes in pertussis transmission networks in communities, and therefore, the prevention of infantile pertussis is the core of prevention and control measures against pertussis including vaccine immunization. Although the cases of pertussis reported in China are mainly infants with pertussis, the actual number of infants with pertussis might be higher than the reported number. It is necessary in clinical practice to improve the awareness of this disease and promote related laboratory tests. On the basis of emphasizing the identification of pertussis in infants, timely diagnosis and treatment, follow-up visits, and standard management of the close contacts of infants with pertussis should be performed to reduce and block the community transmission of pertussis.
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