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[Potential impact of adjusting immunization procedure for diphtheria-tetanus-pertussis vaccine on pertussis in
1National Center for Children's Medicine/Beijing Children's Hospital, Capital Medical University/Laboratory of Infection and Microbiology, Beijing Pediatric Research Institute/National Clinical Research Center for Respiratory Diseases/National Clinical Surveillance Center for Pediatric Infectious Diseases and Allergic Disorders/National Key Discipline of Pediatrics/Key Laboratory of Major Diseases in Children, Ministry of Education/Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Beijing 100045, China.
Abstract:
In recent years, the incidence rate of pertussis in China has been steadily increasing, presenting an increasingly severe challenge for disease prevention and control. To strengthen the immune barrier in the population and effectively curb the spread of pertussis, National Disease Control and Prevention Administration of China and other relevant authorities optimized the immunization procedure for diphtheria-tetanus-pertussis vaccine, with the new procedure implemented in 2025. This adjustment includes three key measures: advancing the initial dose of the vaccine from 3 months to 2 months of age, extending the interval between primary immunization doses from 1 month to 2 months, and adding an extra dose of acellular diphtheria-tetanus-pertussis vaccine at 6 years of age. This article discusses potential changes in the epidemiology and clinical manifestations of pertussis following such adjustments for immunization procedure, and awareness of these changes will facilitate the accurate identification of pertussis cases, which is crucial for evaluating the impact of these adjustments and further optimizing immunization strategies.
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