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Effectiveness of Botulinum Toxin Type A Injection on Scars: A Systematic Review and Meta-Analysis of Randomized
Man-Yun Li1, Wen-Kuan Chiu1, Hsian-Jenn Wang1
1From the Department of Surgery, School of Medicine, College of Medicine, and Division of Plastic Surgery, Department of Surgery, Wan Fang Hospital, Taipei Medical University; the Department of Management of Technology, National Chiao Tung University; SurgMate Company; and the Graduate Institute of Data Science and Research Center of Biostatistics Center, College of Management, the Biostatistics Center, Wan Fang Hospital, the School of Public Health, College of Public Health and Nutrition, the Department of Pharmacy and Research Center for Pharmacoeconomics, College of Pharmacy, the Department of Public Health, School of Medicine, College of Medicine, Cochrane Taiwan, and the Evidence-Based Medicine Center, Wan Fang Hospital, Taipei Medical University.
Botulinum toxin type A (BoNT-A) shows effectiveness in improving scar appearance and reducing width compared to saline. While steroids may be more potent, BoNT-A offers an alternative treatment for scars.
Area of Science:
- Dermatology
- Plastic Surgery
- Regenerative Medicine
Background:
- Scars can lead to significant pain, physical dysfunction, and psychological distress.
- Botulinum toxin type A (BoNT-A) is a potential therapeutic agent for scar management.
- Further clinical evidence is required to validate the efficacy of BoNT-A in scar treatment.
Conclusions:
- Botulinum toxin type A (BoNT-A) is more effective than saline in improving scar characteristics.
- Steroid treatments may offer greater potency for scar reduction compared to BoNT-A.
- BoNT-A serves as a viable alternative treatment option for patients who cannot tolerate or are not amenable to steroid therapy.
