Related Experiment Video
Updated: Aug 28, 2025

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model
Published on: September 9, 2011
Implementation of an Evidence-Based Practice Change Removing Heparin From Implanted Vascular Access Devices
Megan Hoffman1,2,3, Erica Fischer-Cartlidge1,2,3
1Memorial Sloan Kettering Cancer Center, New York, NY (Ms Hoffman and Dr Fischer-Cartlidge).
Heparin is no longer necessary for implanted vascular access device (IVAD) management. Evidence shows 0.9% sodium chloride flushes effectively prevent IVAD occlusion, reducing the need for alteplase.
Area of Science:
- Nursing Practice
- Vascular Access Device Management
- Evidence-Based Practice
Background:
- Heparin has been a standard flush solution for implanted vascular access devices (IVADs).
- Concerns exist regarding heparin's potential risks and the need for effective alternatives.
- Literature suggests saline may be a viable alternative for IVAD maintenance.
Purpose of the Study:
- To describe the implementation and outcomes of removing heparin from IVAD management.
- To evaluate the effectiveness of 0.9% sodium chloride as a replacement flush solution.
- To assess the impact on alteplase administration rates post-implementation.
Main Methods:
- Conducted an extensive literature search and appraisal to identify best practices.
- Implemented a nurse-led initiative to replace heparin with 0.9% sodium chloride for IVAD deaccessing.
- Utilized a pulsatile flushing technique with saline.
- Monitored alteplase administration rates as a key performance indicator.
Main Results:
- Successfully removed heparin from the IVAD deaccess protocol.
- 0.9% sodium chloride with pulsatile flushing proved effective in preventing occlusion.
- No statistically significant change in alteplase administration rates was observed 6 months post-implementation.
Conclusions:
- 0.9% sodium chloride alone is effective for IVAD lock maintenance.
- This evidence-based practice change demonstrates a safe and effective alternative to heparin.
- The findings support the use of saline for IVAD management, potentially reducing medication-related risks.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Venous Thrombosis III: Interprofessional Care
Endocarditis IV: Nursing Management
Venous Thrombosis IV: Nursing Management
Peripheral Artery Disease V: Postoperative Nursing Management
Cardiac Catheterization IV: Nursing Management

