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Lipid-derived Compounds in the Human Body

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Updated: Aug 28, 2025

Assessing Whole-Body Lipid-Handling Capacity in Mice

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

Lipid profiling analyses from mouse models and human infants.

Laurentya Olga¹, Ivana Bobeldijk-Pastorova², Richard C Bas³

¹Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.

|September 17, 2022

Summary

This summary is machine-generated.

This study introduces a translational lipidomic method to identify lipid biomarkers for predicting body composition and organ health changes in early life. The approach validates findings from mice to human studies.

Keywords:

Clinical protocol Health sciences Mass spectrometry Metabolism Metabolomics Systems biology

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Last Updated: Aug 28, 2025

Assessing Whole-Body Lipid-Handling Capacity in Mice

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Lipidomics and Transcriptomics in Neurological Diseases

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Shotgun Lipidomics of Rodent Tissues

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Published on: November 18, 2022

Area of Science:

Biomedical Science
Metabolomics
Translational Research

Background:

Accurate prediction of body composition and organ health during early life is crucial.
Lipid biomarkers offer potential for non-invasive monitoring.
Translating findings from animal models to humans presents challenges.

Purpose of the Study:

To outline a translational lipidomic protocol for discovering lipid biomarkers.
To predict morphometric body and histological organ measurements.
To validate biomarkers from animal models to human cohorts.

Main Methods:

Animal experimentation and histological analysis.
Comprehensive lipid profiling using advanced analytical techniques.
Cross-species validation from mice to human subjects.

Main Results:

The protocol enables the discovery of predictive lipid biomarkers.
Successful translation and validation of candidate biomarkers were demonstrated.
The approach is applicable to various life stages, including early life.

Conclusions:

This translational lipidomic approach is reliable and versatile.
It facilitates the identification and validation of lipid biomarkers for predicting physiological changes.
The protocol supports the advancement of precision medicine in developmental studies.