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Recent progress in single-atom nanozymes research.

Bing Jiang1, Zhanjun Guo1, Minmin Liang1

  • 1Experimental Center of Advanced Materials, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing, 100081 China.

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|September 19, 2022
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Summary
This summary is machine-generated.

Single-atom nanozymes (SAzymes) offer superior activity and stability compared to natural enzymes. This review highlights SAzyme applications in biomedicine, discussing future design and application challenges.

Keywords:
biomedical applicationsenzyme-like activitynatural enzymessingle-atom nanozymes

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Catalysis

Background:

  • Single-atom nanozymes (SAzymes) are emerging as promising alternatives to natural enzymes due to their high activity, stability, and cost-effectiveness.
  • Their unique atomic structure maximizes atom utilization and offers well-defined geometric and electronic properties, leading to enhanced catalytic performance over traditional nanozymes.

Purpose of the Study:

  • To review representative examples of single-atom nanozymes (SAzymes) based on their biomedical applications.
  • To discuss the current opportunities and future challenges in the design and application of SAzymes.

Main Methods:

  • Literature review of recent research on single-atom nanozymes.
  • Categorization of SAzyme examples by biomedical application areas.

Main Results:

  • SAzymes exhibit significant potential in various biomedical fields, including anti-tumor therapy, biosensing, antibiosis, and anti-oxidation therapy.
  • Key advantages of SAzymes include maximized atom utilization, high catalytic activity, and specificity.

Conclusions:

  • Single-atom nanozymes represent a significant advancement in nanozyme technology with broad biomedical potential.
  • Further research is needed to address challenges in SAzyme design and application for clinical translation.