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Related Experiment Video

Updated: Aug 28, 2025

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

3.8K

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording.

Youjin Lee1, Daeho Ryu2, Saeyeong Jeon2

  • 1Department of Electronic and Electrical Engineering, Ewha Womans University; Graduate Program in Smart Factory, Ewha Womans University.

Journal of Visualized Experiments : Jove
|September 19, 2022
PubMed
Summary
This summary is machine-generated.

This study presents a novel implantable optrode array for optogenetics, enabling simultaneous optical neural control and electrophysiological recording. In vivo experiments successfully demonstrated time-locked neural spikes in mouse hippocampal neurons.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Optogenetics

Background:

  • Optogenetics is crucial for neural signaling research, allowing precise control and monitoring of genetically modified neurons.
  • Technological advancements aim to integrate optical stimulation with electrophysiological recording for comprehensive neural analysis.

Purpose of the Study:

  • To develop and evaluate a novel implantable optrode array system for simultaneous optogenetic stimulation and neural recording.
  • To demonstrate the system's efficacy in in vivo experiments.

Main Methods:

  • Development of an implantable optrode array with 2x2 optical fibers and multichannel electrodes.
  • Integration of a light-emitting diode (LED) light source and a microfabricated microlens array.
  • In vivo implantation in mice for optogenetic light stimulation and electrophysiological recording of hippocampal neurons.

Main Results:

  • Successful implantation and operation of the optrode array system.
  • Demonstration of time-locked neural spikes in hippocampal excitatory neurons evoked by light stimuli.
  • Validation of the system's capability for simultaneous neural modulation and monitoring.

Conclusions:

  • The developed implantable optrode array system is effective for optogenetic investigations.
  • This technology facilitates simultaneous optical control and electrophysiological recording of neural activity.
  • The system shows promise for advancing research in neural signaling and brain-computer interfaces.