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Association Between Hypercholesterolemia and Neck Pain in a Cross-sectional Population-based Study.

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Individuals with hypercholesterolemia are 54% more likely to experience neck pain. Managing high cholesterol may help prevent or slow degenerative cervical disk disease and associated neck pain.

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Area of Science:

  • Orthopedics
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • Degenerative changes in the cervical spine are a primary cause of chronic neck pain.
  • The vascular hypothesis suggests atherosclerosis contributes to disk ischemia and degeneration.
  • Prior research links atherosclerotic risk factors to lumbar degenerative disease, with potential implications for cervical disks.

Purpose of the Study:

  • To investigate the association between hypercholesterolemia and the prevalence of neck pain.
  • To determine if hypercholesterolemia is an independent risk factor for neck pain.

Main Methods:

  • Retrospective cross-sectional analysis of the 2018 Medicare Expenditure Panel Survey (MEPS).
  • Analysis included 30,461 participants, focusing on those reporting neck pain.
  • Logistic regression analyses adjusted for demographic, educational, and mental health factors.

Main Results:

  • Neck pain was reported by 3.4% of participants (n=1049).
  • Overall neck pain prevalence was 21.1%, with higher rates in white individuals, lower income, and smokers.
  • Hypercholesterolemia was significantly associated with a higher prevalence of neck pain (adjusted odds ratio=1.54, P=0.018).

Conclusions:

  • Hypercholesterolemia is linked to a 54% increased likelihood of neck pain, independent of other factors.
  • This finding supports a role for hypercholesterolemia in cervical spine degeneration.
  • Effective management of high cholesterol may reduce the incidence and progression of degenerative cervical disk disease and neck pain.